John Crowley may be the once-and-future- CEO of Amicus Therapeutics, but he will not be a U.S. Senate candidate this year. Crowley, who stepped down as CEO at Amicus in April and triggered broad speculation that he would run as a Republican senate candidate against incumbent Democrat Bob Menendez in 2012, will resume his position as chairman and CEO as of August 15.

According to Amicus, Crowley will resume his former position after he completes temporary active duty with the U.S. Navy Reserve. In April Crowley said that he wanted to “devote more time to interests related to public policy, civic service, and philanthropic endeavors.”

Matthew Patterson, the company’s president and COO, replaced Crowley as acting CEO, but will resume his previous duties when Crowley returns. Crowley’s role as executive chairman is suppose to end in October, but could be extended by three months if Crowley and the company agree.

This is not the first time Crowley has stepped away from speculation that he would run for high office. He was courted in 2008 as a challenger to Senator Frank Lautenberg, but declined to run. A year later he was on the short list for a run at the governor’s office.

After he stepped down from Amicus’ top post in April Republican organizations around the state wasted no time championing Crowley, whose personal story has all the earmarks of an ideal candidacy. He attended the U.S. Naval Academy in 1986 and 1987, before transferring to Georgetown University to get his bachelor’s in foreign service. He is an intelligence officer in the Naval Reserve. He married his high school sweetheart, Aileen, in 1990. He built two successful biotech companies and made himself a millionaire, which was something supporters liked because it meant that he, like former Democratic Governor Jon Corzine, could self-finance a Senate run.

Crowley’s most compelling story involves his quest to cure Pompe disease, a condition that causes a deficiency in the enzyme that breaks down glycogen. Its buildup in the body causes extreme muscle weakness, and it affects his two youngest children, Megan and Patrick, who were diagnosed in 1998.

Crowley, who at the time was an executive at Genzyme, left his position to raise capital for Amicus. He raised $100 million and the story became the subject of a book titled “The Cure: How a Father Raised $100 Million and Bucked the Medical Establishment In a Quest to Save His Children.” In 2010 the story was made into the movie “Extraordinary Measures,” starring Brendan Fraser as Crowley (U.S. 1, January 20, 2010).

Crowley also holds a J.D. from Notre Dame Law (1992) and an MBA from Harvard (1997).

#b#Amicus Therapeutics#/b#, 5 Cedar Brook Drive, Cedar Brook Corporate Center, Cranbury 08512; 609-662-2000; fax, 609-662-2001. Matthew Patterson, acting president and CEO.

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