Medical Devices

Devices for Testing

Derma/Skin Delivery

Hydrogel Devices

Drug Delivery

Electronic Biotech

Corrections or additions?

Published in U.S. 1 Newspaper on May 17, 2000. All rights

reserved.

Princeton’s R&D Community: Part I

Some editor once said that if newspapers didn’t have to cover all the

news, they’d be able to tell people what is really going on.

This week we held back on our news pages, the Life in the Fast Lane

section with its usual assortment of moves, start-ups, and expansions,

and instead have devoted all the space to details on a cross-section

of Princeton’s 250 R&D companies that aren’t ready to make news —

yet. These companies are quietly at work making products that will be

newsworthy in the months and years to come.

We print these R&D listings at regular intervals to show the breadth

and depth of Princeton’s research community. This issue focuses on the

medical device firms, but we packed in as many as we could from the

other types of companies that responded to our faxed request for

information. They represent well over 15,000 Central Jersey workers

engaged in biotechnology, electronics, chemistry, or pharmaceuticals

— and that doesn’t begin to count all the service companies who are

paid to do ancillary services such as lab work, clinical research,

marketing, and so on.

These four dozen listings represent just one-sixth of Princeton’s R&D

companies overall. We did try to list each and every medical device

company, so you’ll get the complete picture of that area. But as for

all those that do drug delivery, combinatorial chemistry, imaging, and

gene sequencing — or those that operate even further afield, in the

areas of electronics and multimedia, for instance — we had room only

for those companies that responded to our information request. See the

complete array in the U.S. 1 Business Directory, partially available

online at www.princetoninfo.com/bizdir.html.

Top Of Page
Medical Devices

Artegraft Inc., 220 North Center Drive, North

Brunswick 08902; 732-422-8333; fax, 732-422-8647.

www.artegraft.com.

Founded 1993. Richard A. Gibson, president and CEO. Staff size: 7.

Square feet: 4,500.

Medical device manufacturing — vascular access grafts

made from cow arteries for hemodialysis, chemically processed and

permanently implanted.

Convatec, a Bristol-Myers Squibb Company, 100

and 200 Headquarters Park Drive, CN 5254, Princeton 08543-5254;

908-904-2500;

fax, 908-281-2687. www.convatec.com. Founded 1978. Gary Restani,

president. Staff size: 300.

Manufacturer of ostomy, wound, and skin care products,

and continence care products.

EchoCath Inc., 4326 Route 1 North, Box 7224,

Princeton 08543-7224; 609-987-8400; fax, 609-987-1019. Stock symbol:

ECHTU. Frank DeBernardis, president. Staff size: 15.

Research and development of high tech medical devices.

Just approved: EchoFlow technology provides flow data from vessels

for vascular and coronary bypass surgery. Future applications will

include feedback control of pacemakers and implantable defibrillators.

EchoEye technology will eventually allow clinicians to view tissues

and organs inside the body in 3-D real-time and provide intravascular

images and guidance for minimally invasive ultrasound guided

procedures.

FEI Technologies, 109 Morgan Lane, Plainsboro

08536-9636; 609-897-0809; fax, 609-897-9636. Founded 1992. Staff size:

14. Square feet: 2,200.

Manufacturer of copper intrauterine devices.

Top Of Page
Devices for Testing

i-STAT Corporation, 104 Windsor Center Drive,

East Windsor 08520; 609-443-9300; fax, 609-443-9310.

www.i-stat.com.

Stock symbol: STAT. Founded 1984. William P. Moffitt, president and

CEO. Staff size: 150.

Diagnostic blood analysis equipment manufacturing. In

March 2000 i-STAT became the first company in history to offer blood

gas, electrolyte, metabolite, glucose, and coagulation testing on

a single platform. Also new, an i-STAT Analyzer that combines the

testing capabilities of i-STAT and Abbott/Medisense into a single

hand-held instrument.

Medical Indicators Inc., 1589 Reed Road,

Pennington

08534; 609-737-1600; fax, 609-737-0588.

www.medicalindicators.com.

Founded 1985. Ronald Benincasa, president. Staff size: 28.

Manufacturing and R&D of liquid crystal thermometers for

baby and adult use. Production of 20 million thermometers annually,

including TraXit, a double-sided heart-shaped adhesive, placed under

a child’s armpit, that provides 48-hour monitoring. To come: method

for basal body temperature studies for women of reproductive age and

a baby bottle that would heat uniformly in a microwave oven.

Princeton BioMeditech Corp., 4242 Route 1 North,

Box 7139, Princeton 08543-7139; 732-274-1000; fax, 732-274-1010.

Founded

1988. Jemo Kang, president. Staff size: 85. Square feet: 25,000.

PBM Technologies, R&D and manufacture of advanced medical

rapid diagnostic products, or one-step blood and urine tests for

pregnancy,

ovulation, drug use, rubella, and mononucleosis.

Sensors Unlimited, 3490 Route 1, Building 12,

Princeton 08540; 609-520-0610; fax, 609-520-0638.

www.sensorsinc.com.

Founded 1991. Gregory H. Olsen, president. Staff size: 80. Square

feet: 11,000.

World-leading fiber optic component design, fabrication,

and supply. Manufacturers of infrared detectors, cameras with infrared

detectors, infrared focal-place-arrays and infrared lasers. The

products

are used in diverse applications such as medical, non-invasive blood

analysis, agricultural sorting, masters’ artwork analysis, military

communications and telecommunications.

One project currently under development is a non-invasive

glucose monitoring kit for home use, being developed with several

other companies around the world. The detector reads the amount of

sugar in the blood of a finger held up to it. Another use will be

for blood alcohol readings.

For agricultural product sorting, a detector can determine

ripeness of fruit, based on sugar content, sort rice from chaff, and

sort nuts from shells, as in making candy. Also in development,

wavelength

division multiplexing — for more efficient fiber optics. Instead

of sending one wavelength down a fiber there could be up to 64

wavelengths

on a fiber.

Unipath Diagnostics Co., 47 Hulfish Street, Suite

400, Princeton 08542; 609-430-2727; fax, 609-430-1197.

www.clearplan.com.

Stock symbol: UNLV. Founded 1997. Patricia Nasshorn, president, U.S.

division. Staff size: 23. Square feet: 7,100.

A division of the U.K.-based Unilever, the marketing arm

for a complete line of women’s reproductive diagnostics, including

ClearBlue Easy One Minute Pregnancy Test (the first one-step home

pregnancy test), the ClearPlan Easy Ovulation Test (the first one-step

test of its kind), and the ClearPlan Easy Fertility Monitor, a $199

palm-size computer that uses urine tests to pinpoint the exact days

in a woman’s cycle when conception is most likely (U.S. 1, November

17, 1999). The data can even be downloaded to a computer so the

ongoing

personal fertility data — including the Intercourse Event Card

— can be printed out and shared with a physician or partner.

Unipath

also launched the Fertility Talk campaign to educate women to make

informed choices about their reproductive healthcare.

Top Of Page
Derma/Skin Delivery

Derma Sciences Inc., 214 Carnegie Center, Suite

100, Princeton 08540; 609-514-4744; fax, 609-514-0502.

www.dermasciences.com.

Stock symbol: DSCI. Founded 1984. Edward J. Quilty, CEO. Staff size:

8.

Full range of wound management and skin care products,

total of 60 employees.

Galderma Research and Development Inc., 5 Cedar

Brook Drive, Suite 1, Cranbury 08512; 609-409-7701; fax, 609-409-7705.

www.galderma.com. Janusz Gernielewski, president. Staff

size: 35. Square feet: 58,987.

Research and development of dermatology pharmaceutical

products, owned by L’oreal and Nestle, headquarters in France.

Hy-Gene Inc., 36 South Broad Street, Box 9017,

Trenton 08650; 609-291-8683; fax, 609-291-1997. www.hy-gene.com.

Founded 1987. John J. Wille, president and COO. Square feet: 650.

Tissue engineering and medical device company working

on autologous cloned skin grafts (for treatment of burns, chronic

wounds, and other tissue replacement uses) and an emulsion-based drug

delivery technology.

Integra LifeSciences Corporation, 105 Morgan

Lane, Box 688, Plainsboro 08536; 609-275-0500; fax, 609-799-3297.

www.integra-ls.com. Stock symbol: IART. Founded 1989. Stuart

M. Essig, president/CEO. Staff size: 169. Square feet: 35,000.

Tissue and organ replacements, including artificial skin,

cartilage, and nerve conduits. Integra Artificial Skin is a bi-layer

membrane system for skin replacement.

NexMed Inc., 350 Corporate Boulevard,

Robbinsville

08691; 609-208-9688; fax, 609-208-1868. www.nexmed.com. Stock

symbol: NEXM. Founded 1987. Joseph Mo, chairman, CEO, and president.

Staff size: 15. Square feet: 11,000.

Topical creams for sexual dysfunction for men and women.

U.S. Dermatologics Inc. (USD), 133 Franklin

Corner

Road, Lawrenceville 08648; 609-219-1166; fax, 609-219-1188. D.

Brooks Cole, president.

Patented patch therapy for treating common topical skin

problems such as acne and fungal infections.

Top Of Page
Hydrogel Devices

Hydro Med Sciences, 8 Cedar Brook Drive, Cedar

Brook Corporate Center, Cranbury 08512; 609-409-9010; fax,

609-409-1650.

www.hydromed.com. Stock symbol: GPX. Founded 1972. David Kunin,

vice president. Staff size: 20. Square feet: 12,000.

Manufacture of topical and implantable drug delivery

devices,

a division of GP Strategies Corporation. Hydron Implant — a

proprietary

subcutaneous hydrogel retrievable device that can deliver a broad

spectrum of therapeutic compounds at controlled, constant release

rates for up to one year and longer.

Hymedix Inc., 2245 Route 130, Suite 101, Dayton

08810; 732-274-2288; fax, 732-274-2426. www.hymedix.com.

Stock symbol: HYNX. Charles K. Kliment, CEO. Staff size: 15. Square

feet: 20,000.

Cosmetics, proprietary hydrogels, drug delivery systems,

wound care products, lubricious coatings, implants, sensors, etc.

Replication Medical Inc., 5 Crescent Avenue,

Princeton Business Park, Suite B-1, Box 739, Rocky Hill 08553-0739;

609-921-2854; fax, 609-683-8768. Founded 1980. David Anderson,

president.

Staff size: 5. Square feet: 2,600.

Orthopedic applications of hydrogels for replacement of

nuclei in spinal disks, also prevention of scar tissue formation,

formerly Biomimetics.

Top Of Page
Drug Delivery

Delsys Pharmaceutical Corporation, 11 Deer Park

Drive, Suite 202, Monmouth Junction 08852; 732-329-3407; fax,

609-520-6692.

www.delsyspharma.com. Founded 1997. Martyn Greenacre, president

and CEO. Staff size: 54. Square feet: 2,500.

A Sarnoff Corporation spinoff that develops dry powder

electrostatic deposition technology to formulate and manufacture

proprietary

pharmaceutical dosage forms. By accurately depositing only the drug

substance onto a film the technology enables unique products,

simplifies

manufacturing, and allows the drug content of each individual dosage

unit to be measured. Delsys also expects its Accudep technology to

expand the market opportunities for many marketed drugs as well as

streamline the formulation process for compounds in development.

EpiGenesis Pharmaceuticals Inc., 2005 Eastpark

Boulevard, Cranbury 08512; 609-409-6080; fax, 609-409-6126.

www.epigene.com.

Founded 1995. Jonathan W. Nyce PhD, chairman and CEO. Staff size:

15. Square feet: 5,100.

Drug discovery and development company focusing on

respiratory

diseases. Drugs delivered to target tissue, discovery of genetic basis

for such diseases as asthma, chronic obstructive pulmonary disease,

chronic bronchitis, respiratory infections, and lung cancer.

Gynetics Inc., 105 Raider Boulevard, Suite 203,

Belle Mead 08502; 908-359-2429; fax, 908-359-6660.

www.gynetics.com.

Jack E. Stover, chief operating officer.

Development and marketing of drugs and devices to advance

women’s health, specifically emergency contraception kits.

Lavipharm Laboratories Inc., 69

Princeton-Hightstown

Road, East Windsor 08520; 609-448-3001; fax, 609-371-9174.

www.lavipharm.com.

Founded 1911. Zsolt E. Lavotha, president and CEO. Staff size: 30.

Square feet: 50,000.

A new proprietary transdermal patch for treating skin

blemishes — the pHisoderm Blemish Patch — is sold in drug,

mass merchandise, and grocery stores. Lavipharm says it developed

this technology first and is the only firm to use it to market a

cosmetic

patch. In Europe, where it has been available for four years, the

patch is sold as Normaderm/Vichy, Synergie, Jade, and Plenitude. It

delivers a concentrated formula of salicylic acid, triclosan, and

chamomile to reduce the blemish, kill bacteria, and soothe the skin

within six to eight hours. Other patches are for patches for

anti-wrinkle,

cleansing, reducing eye puffiness and dark circles, healing dry skin,

and lightening age spots.

The firm’s base technologies are Microparticulate

Solubilization

Technology (to increase water solubility) and Supercritical Fluid

Applications. It works with transdermal drug delivery systems (selling

a nitroglycerine patch under a variety of trade names), intraoral

delivery systems, Quick-Dis (fast-dissolving systems for pain

management

erectile dysfunction, and asthma), and Slow-Dis (slow-dissolving

system

for cardiovascular drugs, and respiratory therapies).

MicroDose Technologies Inc., 4262 Route 1 North,

Suite 3, Monmouth Junction 08852; 732-329-2401; fax, 732-329-8502.

www.microdose-tech.com. Founded 1996. Anand V. Gumaste PhD,

president and CEO. Staff size: 14. Square feet: 7,500.

Development of pulmonary, oral, and transdermal drug

delivery

systems, and a broad, patented product portfolio of drug delivery

systems. This hand-held, low cost breath-activated MicroDose inhaler,

the first totally electronic dry powder inhaler, uses innovative

"piezo

electronics" technology to efficiently deliver such asthma drugs

as budesonide and fluticasone as well as smoking cessation and acute

pain management drugs. Testing indicates superior performance and

easier use compared with existing inhalers, and the reaction from

major pharmaceutical companies has been very enthusiastic. This

patented

drug delivery system could extend the patent life of proprietary drugs

that have outlived their patents.

Seven companies are testing their compounds in the

MicroDose

inhaler, and officials expect to sign two licensing and development

agreements by the end of this year. With a UK-based company, Quadrant

Healthcare plc, MicroDose is using formulation and particle

engineering

technology to develop an inhaler that will deliver peptides and

proteins

via the lungs. The first would deliver rapid acting insulin. Human

trials for inhaleable insulin will are scheduled for the fourth

quarter

of this year.

Another technology, the MicroDose electrostatic deposition

system (MEDS), transfers electronic printing technology to

pharmaceutical

manufacturing. It helps solve the previously unsolvable problem of

how to package small quantities of powdered drugs. It is used to fill

drug containers and unit dose blisters. It also helps produce new

solid oral dosage forms with controlled release and site specific

release characteristics to bring new life to drugs soon to go off

patent. It can also speed up clinical trials by rapidly producing

a variety of oral dosage forms at the rate of thousands of unit doses

a day.

Future products for this company include needle free

injection

systems, a handheld nebulizer, and a programmable transdermal patch.

Nika Health Products Inc., 4519 Provinceline

Road, Princeton 08540; 609-921-0089; fax, 609-688-10031. Founded 1988.

Wojciech Piasecki, director. Staff size: 4.

Discovery and r&d of proprietary platform technologies

involving the treatment of infectious diseases, also virosome delivery

systems for drug and gene therapies.

Pharmaceutical Quality Associates, 20 Nassau

Street, Suite 202, Princeton 08542; 609-683-9484; fax, 609-683-9487.

Founded 1995. Leonard Kaplan PhD, president. Staff size: 3.

Consulting services and product development of oral and

topical drug delivery systems. Patents have been filed for a new low

cost AIDS intradermal treatment that is administered along with

conventional,

more expensive regimens to immuno-suppressed individuals infected

with HIV. This treatment increases CD4 lymphocyte counts.

Therics Inc., 115 Campus Drive, University

Square,

Princeton 08540; 609-514-7200; fax, 609-514-7219.

/www.therics.com.

Founded 1993. Jim Wavle, president/CEO. Staff size: 43. Square feet:

23,000.

Manufacturing of medical products using TheriForm, a

fabrication

process with three-dimensional printing.

Top Of Page
Electronic Biotech

High Power Devices (HPD), 1200-A Airport Road,

New Brunswick 08902; 732-249-2228; fax, 732-249-8139.

www.hpdinc.com.

Founded 1995. Tom Moritz, CEO. Staff size: 20. Square feet: 8,000.

Manufacturer of semiconductor lasers for medical, pumping,

lidar (laser radar) and other military and commercial applications.

HPD is on the leading edge of supplying components for ophthalmic

applications and various lasers for photodynamic therapy.

MMTC, 12 Roszel Road, Suite A 203, 205, Princeton

08540; 609-520-9699; fax, 609-520-9859. www.mmtc.com. Founded

1987. Fred Sterzer, president. Staff size: 8.

Microwave technology research for cancer diagnosis &

therapy,

treatment of benign prostatic hypertrophy, wound healing, and adult

sleep apnea. cancer diagnosis and therapy, treatment of benign

prostatic

hypertrophy, wound healing, adult sleep apnea

Physiome Sciences, 307 College Road East,

Princeton

08540; 609-987-1199; fax, 609-987-9393. www.physiome.com.

Founded 1994. Jeremy M. Levin, president and CEO. Staff size: 28.

Square feet: 8,000.

Software products to simulate biological processes on

the computer. On its $2 million supercomputer this firm operates a

fully functional, three-dimensional, interactive model of a working

heart, a detailed math-based model of how the heart actually works

(U.S. 1, May 13, 1998). The virtual heart provides a quantitative,

comprehensive, verifiable, and usefully predictive model of the heart

based on the properties of the heart’s individual cells and the

biochemical

functions they perform. It breaks down the millions biological

processes

going on inside the heart, describes them as mathematical equations,

and then assembles them and all their actions and interactions to

create an electronic heart that "works" just like a real one.

The heart can be programmed to have a heart attack, or

develop congestive heart failure, or go into arrhythmia, and it can

help identify and test new potential drugs faster and cheaper than

with traditional animal testing.

Sarnoff Corporation, 201 Washington Road, CN

5300, Princeton 08543-5300; 609-734-2000; fax, 609-734-2040.

www.sarnoff.com.

Founded 1942. James E. Carnes, president & CEO. Staff size: 800.

Square

feet: 600,000.

Creation and commercialization of electronic, information,

and biomedical technologies, client-funded R&D, licensing of

technology,

development and incubation of venture companies. Biotech research

includes imaging technologies.

Sarnoff’s latest technology includes the Acadia I PCI

vision engine, the first plug-in PCI board to add real-time vision

processing power to PCs and workstations for military, medical,

commercial,

and consumer applications. Built around the new Acadia I chip, the

world’s fastest and most powerful vision processor, it allows

Windows-based

PCs to stabilize shaky video to within 1/10th pixel, create seamless

panoramas from successive frames of video, detect and track motion,

and perform other vision processing functions in real time with only

one to two frames of latency. Not other solution is currently

available

for video captured with a moving camera.

At only 1.2 inches square by 1 inch deep Sarnoff’s new

BLINC smart digital camera is ideal for surveillance, automotive,

machine vision, and Internet imaging uses. Built around the CMOS

Active

Pixel Sensor technology, it significantly outperforms conventional

cameras in resolving highlight and shadow detail. It more than 100

times the dynamic range of typical cameras and goes from power-down

to accurate image capture in less than 1/10 second, compared to the

usual two seconds.

Similar technology will be used by Litton Electro-Optical

Systems (LEOS) to create a video-enabled night vision system for the

United States Army Communications Electronics Command (CECOM).

Sarnoff’s CCD (charge-coupled device) technology is the

basis for a government subcontract to develop up to 10 full camera

systems for the U.S. Air Force to trap dim objects in space, such

as U.S. and foreign satellites. A large-format backside illuminated

CCD will allow more precise tracking of objects of lower visibility

than with existing systems. This effort is part of the $5 million

Deep STARE project, awarded to TRW’s Space and Missile Systems

division.

Siemens Corporate Research Inc., 755 College

Road, Princeton Forrestal Center, Princeton 08540; 609-734-6500; fax,

609-734-6565. www.scr.siemens.com. Founded 1977. Thomas Grandke,

president and CEO. Staff size: 150. Square feet: 100,000.

Exploratory and applied research in software engineering,

imaging/optical data processing, and learning systems. One area

concentrates

on rehabilitative and assisting technologies (impaired mobility,

dexterity,

hearing, speech, and vision), home and health automation technologies

for seniors, health care information systems (diagnosis, therapy,

and telemedicine), and health center simulation modeling (predictions

of patient capacity, bottlenecks, and financial returns).

Current research in the areas of pattern detection and

recognition, involves advanced algorithms and techniques for

industrial

and medical applications in order to automate complex visual processes

which were not previously possible. In the area of enhanced virtual

reality, techniques are being developed for rapid construction of

3D models of human organs by integrating image processing and computer

graphics technologies.


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