Clinical Trial Set for OncoSec Product
OncoSec, the Pennington-based cancer immunotherapy company, is one step closer to determining if its TAVO platform can contribute to a successful vaccination for COVID-19.
Together with Providence Cancer Institute, OncoSec has developed a vaccine called CORVax12 which combines the coronavirus spike protein — the piece of the virus molecule that allows it to invade human cells — with interleukin 12 (IL-12), a cytokine protein with the potential to boost the body’s immune response to the vaccine (U.S. 1, June 24). On October 29 the investigational new drug received clearance from the Food and Drug Administration to begin a Phase 1 clinical trial.
The one-year trial conducted by Providence will recruit up to 36 healthy, adult volunteers for an open-label study in which both the patient and healthcare provider are aware of the treatment being used. Patients will receive two doses, spaced four weeks apart. Some subjects will receive a vaccine based on the spike protein alone, while others will receive the spike protein in combination with IL-12.
“CORVax12 leverages TAVO, our clinically established IL-12 platform, and is designed as a next-generation vaccine to evaluate whether TAVO can optimize immune responses of existing vaccines and vaccine candidates to address COVID-19,” said Daniel J. O’Connor, president and CEO of OncoSec, in a statement. “Specifically, should the addition of IL-12 to the SARS-CoV-2 spike glycoprotein facilitate a coordinated immune response more effectively than the SARS-CoV-2 spike glycoprotein alone, this could support the premise that TAVO has the ability to enhance other vaccines currently in development. Additionally, we believe that CORVax12 may also be able to protect those at higher risk for complications from the coronavirus, including cancer, transplant and elderly patients who have compromised immune systems.”
OncoSec, 24 North Main Street, Pennington 08534. Daniel O’Connor, CEO. www.oncosec.com.
Antonio Martillotti, 81, on October 23. He was the owner of Mario’s Pizza on East State Street Extension in Hamilton.
George Lesenskyj, 94, on October 27. With his brother, he established Lawrence Tool and Mold Corp. in 1972.
Lynn Christine Swender, 70, on October 26. She was a legal librarian for the State of New Jersey for 37 years.
Timothy Patrick Gallway Sr., 56, on October 31. He was a warehouse supervisor for Certified Steel Company.
Sydney Sussman, 94, on October 23. He founded Certified Steel and after moving the company to Trenton in the early 1970s began investing in the rehabilitation of neglected industrial and commercial sites in the city. The business also moved on to new construction, including the Station Plaza office and parking complex in the 1980s.