Nitric Oxide: Miracle Drug?

NovoVision: Image Archiving

From Russia: Software Expansion

New in Town: Temporary Offices

Name Changes

Contracts Awarded



Leaving Town

MarketFair Exec Takes Flight

Corrections or additions?

Thess articles were prepared for the June 27, 2001 edition of U.S.

1 Newspaper. All rights reserved.

Life in the Fast Lane

Top Of Page
Nitric Oxide: Miracle Drug?

Popping nitroglycerine pills helps keep lots of people

with heart problems alive, and so does taking aspirin daily. But


is an emergency drug that dilates the blood vessels quickly, and daily

doses of aspirin can trigger stomach ulcers. NiCox, the French


company that has just opened an office at the Carnegie Center, thinks

it might have the perfect combination of nitric oxide and aspirin.

This potential drug could prevent re-stenosis (blood vessels getting

blocked again after an angioplasty) and also inhibit the development

of gastric ulcers.

Nitric oxide is produced by all mammals and a deficit of nitric oxide

has been demonstrated in certain diseases, particularly cardiovascular

ones. Nitric oxide should not be confused with nitrous oxide, known

as laughing gas and used in anesthesia, which has two molecules of

nitrogen and two of oxygen.

Known as NO, nitric oxide consists of one molecule of nitrogen and

one of oxygen. NO is a very simple, very small molecule, but it is

versatile. Exactly how it works is still unclear, but its important

biochemical and physical properties include the capacity to prevent

or repair injury to the gastrointestinal tract, control inflammatory

cell activation, and inhibit the aggregation and adhesion of platelets

to the blood vessels’ inner walls (preventing clotting), says Joel

Morley, U.S. liaison for NiCox.

"It also contributes to the destructive action of certain


cells against tumors, bacteria, viruses, and other


NiCox has more than 140 patents all based on the same principle: to

graft nitric oxide into an existing drug able to release nitric oxide

into the tissue and blood stream in a slow and sustained manner. This

process could rescue the old drugs that are about to lose their patent

protection; it could decrease their side effects, increase their


and perhaps generate new applications that can be considered new


Drugs that NiCox is working on range from Alzheimer’s to asthma.

"One of our products is tagged with aspirin, so you get the


effects on platelet aggregation plus the aggregate effect of nitric

oxide to prevent the development of gastric ulcers," says Morley.

"Aspirin knocks out what protects the stomach from ulceration.

But the nitric oxide acts as a surrogate and puts back what the


blocks." He says that when the drug is administered before a


angioplasty, it cuts down on the incidents of re-stenosis.

"The critical role of nitric oxide has been shown to play in


biochemical processes include pain and inflammation, cardio vascular,

respiratory, dermatology, and urinary problems, and neurodegenerative

diseases," says Morley.

With so many possible uses, NO begins to sound like a panacea touted

by 19th century medicine show hawkers. If it’s so good, why didn’t

we have it before? The problem until about five years ago was


Then three scientists in the mid 1990s successfully grafted nitric

oxide onto another compound, and they won a Nobel prize for this work

in 1998.

Major companies may be quietly working on this research, and small

companies certainly are. NiCox has at least one major competitor,

NitroMed, in the Boston/Bedford area. Both have one of the Nobel


on their advisory board. NiCox has UCLA’s Louis Ignarro, and NitroMed

has Robert F. Furchgott of SUNY Health Sciences Center. "Many

of the other companies’ patents are for nitrites, but we work with

nitrates. And the other companies use a different spacer to attach

the nitric oxide and the drugs," says Morley.

The competitor NitroMed (, is a 40-person firm headed

by Michael D. Loberg, former president of Bristol-Myers Squibb’s U.S.

Primary Care businesses. Its investors include HealthCare Ventures

(which has an office at 44 Nassau Street) and Rho Management (which

is represented on the board by former Princeton resident, Mark


the son of pharmaceutical mogul Jan Leschly). NitroMed has 45 issued

or allowed patents for delivering Nitric Oxide (NO) therapeutics and

has filed for 140 more.

NiCox, in contrast, is located in Sophia Antipolis, outside of Nice.

One of the founders, Elizabeth Robinson, is a 1977 Wellesley alumna

with graduate degrees in chemical engineering and biotechnology from

MIT. She is executive vice president for business development. The

other co-founders are Italian: Michele Garufi, who is chairman and

CEO, and Piero Del Soldato, the executive vice president of science

technology. On the board are Laurent Ganem of Apax Partners, Frank

Baldino Jr., CEO of Cephalon Inc., and Bengt Samuelsson, the Nobel

prize winner, at Karolinska Institute.

"Our philosophy is to bring drugs to an early phase of clinical

development and then to partner the drugs with companies that have

sales and marketing forces," says Morley. Discovery research is

conducted in Milan. Morley will start new drugs through Phase I


trials in this country and look for a pharmaceutical partner by Phase

II. He has six drugs in clinical development now.

Morley met Robinson when he was at Glaxo Wellcome in North Carolina.

He grew up in Kingsport, Tennessee, where his father was a fire


He majored in biology at Tennessee Tech, Class of 1978. After a stint

as a medical technologist he went into pharmaceutical sales with


and Glaxo Wellcome and then did liaison work between the pharmas and

the universities. He and his wife, an internal medicine physician,

live in Bucks County and have four children. NiCox was set up in


to take advantage of the favorable venture capital market there,


says, and in 1999 it began to be publicly traded on the Nouveau


France’s Nasdaq equivalent. It may eventually trade on Nasdaq, but

currently has $80 million to work with.

"Princeton is the perfect location," says Morley, "a hub,

with access to Philadelphia, Newark Airport, and New York." Morley

has hired just one employee since he opened the office, and he is

looking for a regulatory officer, a clinical development officer,

and a project manager. He says his firm hopes to acquire a U.S.-based

company that will come complete with a sales and marketing force.

NiCox Inc., 502 Carnegie Center. Joel Morley, U.S.

liaison. 609-419-1116; fax, 609-419-1117. Home page:

Top Of Page
NovoVision: Image Archiving

Those who file records are often paid at a


pole rate. When those records could mean the difference between life

and death, storing them ever so carefully is worth any amount of time

and trouble. Developments in cyber technology make it possible to

store images both accurately and easily.

Wally Soufi has moved his new company, NovoVision, from Montgomery

Commons to Jefferson Plaza, where he has 16 employees. He offers an

image archive that allows the general user to associate data and to

manage the images in an efficient way — to control access,


what is and isn’t available to certain people — and to easily

retrieve images based on certain search criteria. These images could

be microscopic virtual slides or X-rays often used for medical


"Healthcare is one of the vertical markets that we are attacking,

but the image archiving software has a broader base," says Soufi.

One of his current clients, Pratt and Whitney, uses the image database

to store records of engine materials. Law enforcement is another


client group. One of the earlier products he developed under license

to another vendor is being used in police departments for


of crime suspects.

"We allow our customers to capture their images using any variety

of digital camera and video cameras," says Soufi. "Some are

high definition, some are basic cameras. We store them with our


and make those images available to them."

Though the software is for archiving images, it has some unique


and can meet the stringent requirements of pathologists, for example.

"They must capture demographic and quality control information,

and they need to know who is doing what on the system," says


"Our software allows them, among other things, to integrate the

images in the final report."

Soufi is working with another startup company to prepare virtual


"We start out with a slide and take it through the histology


process, but we come up with a really high definition image so that

the user would not have to actually look at the microscope again to

see the details of the slide." As for the engineers, engine


must consider metal fatigue and stress conditions. A failure analysis

group photographs the parts of an engine, exposes them to stress


and then takes the pictures again. Those before and after photos are

put into the image archive.

"Several vendors are trying to accomplish the same task,"

Soufi admits. "But we have high tech access codes suitable for

`export controlled’ government use, and our images can be higher than

4,000 pixels. Also, we can save data with images, and save sounds."

Like most founders of small companies, Soufi carries two sets of


cards, one acknowledging that he is chairman, CEO, and president,

and one that uses the title of product manager. "Chairman and

CEO doesn’t work well in a sales situation," he says.

A native of Tripoli, Lebanon, Soufi, 35, is the son of a


An electrical engineer with a master’s degree from Cornell, Soufi

worked as a computer consultant for various companies and got his

start with this product at a laboratory in Florida.

Soufi has established a line of credit with Sovereign

Bank, and Marilyn Jerry of Jerry & Jerry at 760 Alexander Road is

his attorney. "She was instrumental in drafting initial contract

with our customers in Florida," he says. Another important contact

was Katherine Kish, whom he retained as a business consultant. "I

found her name in a U.S. 1 ad and have been working with her for all

of last year."

Says Kish: "Wally really understands the problems to be solved

in the pathology laboratory and how to categorize and archive images

to assist in the process. Errors are an enormous problem in


Any product that can lower the incidence of error would be


"So far," says Soufi, "the clients maintain the images

on their own property and we supply the software, but we are about

to put those images on our servers."

"We are going through quite a bit of growth and are starting to

think about new capital. As a long term goal, I would like to be able

to see us become a publicly traded company with a serious value for

investors. Short term, I have to focus on sales."

"It took a lot of courage to start my business," he says.

"I am still not very comfortable with the risk factors involved

in what I do. But I feel that if there is a time to do it, now is

the time. Thoughts of `what if’ things don’t work will only hold you

back. This is the way for me to grow and fulfill my potential."

NovoVision Inc., 27 Jefferson Plaza, Princeton

08540. Wally Soufi, product manager. 877-668-6123; fax, 877-668-6124.

Home page:

Top Of Page
From Russia: Software Expansion

What 10-person software company wouldn’t like to have

Allstate as its major client? That is the fortunate position in which

Vladimir Bernstein, founder of SimX Corporation, finds himself. Though

he is now "safe in the hands of Allstate," as the jingle likes

to say, Bernstein hopes to sign up more insurance companies soon:

"Our ultimate goal is to make a `killer application’ and package

it for other clients." Earlier this month he moved into an office

suite on Route 130.

Bernstein, 50, went to the Moscow Institute of Energy Technology.

He emigrated from Russia 10 years ago on an H-1B visa and a year later

was followed by his wife and their two young sons (now 15 and 22).

He and his partner, Andri Afanssenkov, started their own firm in 1993.

They started out consulting for Continental Insurance, later known

as CNA, and that division was bought out by Allstate. Then they worked

for Sasha Migdal, also a Russian emigre, at Real-Time Geometry (now

Metacreations) on three-dimensional manipulation of visual computer

data. (Migdal’s company now belongs to the Manhattan-based ViewPoint.)

SimX employs 10 people — including Nikita, Vladimir’s son —

and hopes to grow quickly. Bernstein’s software would put all the

functions of a company on the web with minimal programming. It is

a components-based system, like a software Lego, in that it uses the

components visually to build complicated applications for various

levels and functions.

On a low level, the software does data warehousing. On the next level,

it offers local reporting and data processing diagnostics. It can

also build datamarts, which are necessary for high level reporting.

For now, SimX is working with management’s information, not with


that goes to customers.

Asked why Russian emigres are flourishing in technical businesses,

he cites his country’s scientific tradition: "We were raised in

an atmosphere that there is nothing better than work," he says.

"We didn’t have any other opportunities. Now it is too late to

change our habits. The next generation knows how to enjoy life."

"We also have the ability to see the abstract nature of the


— the big picture. One of the typical problems we faced here,

is that there are a lot of very smart people, but they are focused

on what they are doing. That is good, because they are achieving high

quality results. But they are missing the big picture."

SimX Corporation, 510 Route 130, Suite 15, East

Windsor 08520. Vladimir Bernstein and Andri Afanssenkov, 609-371-8495;

fax, 609-371-5324. Home page:

Top Of Page
New in Town: Temporary Offices

Regus (REGS), 100 Overlook Center, Second Floor,

Princeton 08540. Christopher Perez, sales manager. 610-727-3992; fax,

610-727-4005. Home page:

The largest provider of flexible office space in the

world is opening a 38,000 square-foot branch on the second floor of

Princeton Overlook on Monday, July 23. Rentals can be as short as

one-half day. At this location an office will rent for $22 for one

day, and a meeting room will cost for $50 for half a day. An


office, a mailing address and telephone, will cost $175 per month.

The owner/landlord of this building, Mack-Cali, was represented by

Diane Chayes, senior director of leasing.

Regus’ company history recounts how founder Mark Dixon had wanted

to expand his bread baking business but had trouble finding short-term

office space. Now his shared office business has 490 locations, is

expanding at the rate of 200,000 square feet per month, and is a


company with a $2 billion market cap. Company policy is that real

estate agents who refer new customers to Regus will receive what is

termed "a substantial introduction fee."

Perez, the sales manager, grew up in Drexel Hill, a western suburb

of Philadelphia, where his father was an insurance agent. He went

to the University of Rochester, Class of 1991. He has owned a sports

bar in Media, Pennsylvania, and did commercial financing for real

estate before joining Regus.

Regus started in Belgium, and is now based in Purchase, New York.

It has just opened a branch on the 93rd floor of the World Trade


and a branch in Bridgewater is scheduled for next March. Although

HQ (which has a branch at Forrestal Village) has more offices in the

United States, Regus has more offices globally, Perez says. "Our

average location is a lot bigger than their average location."

The Princeton Entertainment Organization, 1580

Reed Road, Pennington 08534. 609-737-3500; fax, 609-737-8041.

Ed Kasses is a New York producer who hated commuting to New Jersey

and moved to a quiet little four-person office on Reed Road. He


live entertainment, television shows, and tours for orchestras and

popular recording artists, and among his more eminent clients are

the Kennedy Center and John Lithgow. In fact, he met the latter at

the former.

Though he likes to attract publicity for his clients, Kasses is shy

of the spotlight himself, as befits the experienced producer. "Put

the spotlight on my client," he likes to say.

Carpenter East West, 2 Marlen Drive, Hamilton


A.C. Diwan, president/owner. 609-631-9000; fax, 609-689-3091. Also

Carpenter Emergency Lighting, 609-689-3090.

Carpenter Emergency Lighting assembles and sells emergency lighting

fixtures and exit signs. Its sister company, Carpenter East West,

just moved here from Virginia. It is involved in foreign trade.

Top Of Page
Name Changes

Kirlin Securities (KILN), 100 Canal Pointe


Suite 206, Princeton 08540. Joe Betti and Patrick Heher, branch


609-987-0500; fax, 609-987-1715. Home page:

Princeton Securities, a full-service broker and market maker

in over-the-counter stocks founded by Ken Kamen and Steve Taromina,

has changed its name to Kirlin Securities. It had been bought by a

subsidiary of Long Island-based Kirlin Holdings in April but was kept

as a separate entity until now. Joe Betti and Patrick Heher are branch

managers here. Betti majored in accounting at Villanova University,

Class of 1990.

Kirlin Securities is in acquisition mode, and if the most recently

announced purchase goes through, it will have 250 employees (with

200 registered representatives) and seven locations. Still, compared

to the well-known broker dealers, it is tiny.

"We are tiny to the large firms, but we are looking for the


slice of the pie," says Anthony J. Kirincic, co-founder and


"Most of our clients have from $50,000 to $200,000 to invest.

At Morgan Stanley, with $100,000, they want to send you to a service

center — a help desk with an operator."

Kirlin Holding Corp., co-founded by CEO David O. Lindner, is engaged

in retail securities brokerage, investment and merchant banking, money

management and E-commerce activities. In addition to Princeton


it recently bought First Long Island Securities, and it is in the

process of purchasing M.S. Farrell, with locations in Red Bank, New

York, and Fort Lauderdale.

Anthony F. Dwyer, the chief market strategist, seems ubiquitous with

regular appearances on CNNfn, The, Yahoo, AOL, and


Kirlin’s website features Dwyer’s daily commentary with such


titles as "Fear is normally worse than reality," "Patience

my friends," and "Wait till you see the whites of their


Talking about the recent stock market downturn, Kirincic says the

Long Island brokerage started out as a fixed income firm and has a

lot of conservative investments. "About 20 percent of our client

base invests in fixed income, in contrast to Princeton, which started

out as an over the counter market maker, where most clients were 100

percent in stocks," he says.

"Two years ago, trying to sell anyone a bond, when they were


25 percent in the stock market, was like selling ice in the


Recent market volatility has reminded people that markets go in two

directions and that including fixed returns, such as bonds, in a


portion of their portfolio, is a good method of allocating their


says Kirincic. "Now we can go back to finding good places to


people’s money. It is all about expectations and expectations got

too high."

Top Of Page
Contracts Awarded

Nassau Broadcasting Company, 619 Alexander Road,

Princeton 08540. Louis F. Mercatanti. 609-452-9696; fax, 609-452-6017.

Millennium Radio Group of Amherst, New York, has bought five of Nassau

Broadcasting’s Jersey radio stations for $90 million. CEO Louis


sees this sale as the alternative to last year’s plan to raise $200

million by going public. Earlier this year Millennium had purchased

NJ101.5 FM in Trenton, and three stations in Atlantic City. Its Nassau

Broadcasting acquisitions are in Asbury Park, Toms River, Lakewood,

and Ocean Acres. Millennium expects to get Federal Communications

Approval for this expansion by September.

Senesco Technologies Inc. (SENO), 34 Chambers


Princeton 08540. Ruedi Stalder, chairman and CEO. 609-252-0680; fax,

609-252-0049. Home page:

The three-year-old gene discovery firm announced on June 14 that it

has achieved its goal, to extend the shelf life of cut carnations.

The cut flowers last 12 days, instead of the previous six days, if

they have been genetically engineered.

This is good news for florists, because the current "fountain

of youth" for flowers, silver thiosulfate to slow down


aging, has been criticized for being toxic.

Top Of Page

SimStar Internet Solutions, 202 Carnegie Center,

Princeton 08540. David Reim, president. 609-252-9741; fax,


Home page:

The E-business solutions firm has made its move from 16,000 feet in

several locations at Research Park to 30,000 feet at the Carnegie

Center 202 (U.S. 1, May 23). It does strategy, development, and


of E-business solutions for the pharmaceutical and healthcare


COMQuest Research LLC, 3131 Princeton Pike,


4, Suite 200, Lawrenceville 08648. 609-219-0759; fax, 609-219-1888.

Home page:

COMQuest Research moved from 1,000 square feet to 2,500 square feet

within the same building. For Fortune 50 companies, it does market

research, analysis, and consulting services in brand image and


satisfaction. Principals are Robert Clark, Gary Ocher, and Jeff Brown.

Schreck Bavaro & Company LLC, 342 Wall Street,

Princeton 08540. Michael J. Bavaro, partner. 609-430-1500; fax,


The CPAs, who also have an office at 10 Park Place, Morristown, have

moved from 1,000 square feet at 43 Wall Street to larger quarters

at 342 Wall Street.

Morgan Stanley, 212 Carnegie Center, Princeton

08540. Vikki Hiel, office manager. 609-750-9244.

Morgan Stanley has moved into 33,686 square feet at 212 Carnegie


after occupying temporary space in the Covance building. Patrick Luzzi

and Greg Lezynski of Gale & Wentworth represented the tenant in the

long-term lease, and John K. Brandbergh did the lease for Boston


The building has a total of 159,000 square feet and used to be solely

occupied by Covance. Now it also has Velio Communications and Exide

Corporation as tenants.

Top Of Page

Webcraft-Vertis Direct Marketing Services, Route

1 & Adams Station Road, Box 6023, North Brunswick 08902. 732-297-5100;

fax, 732-821-3740. Home page:

In a consolidation of space, the accounting department of Webcraft

moved from 205 North Center Drive to the Adams Station Road building.

The firm does direct marketing and printing. This web offset printing

operation produces direct response packages. It had 300 people here

plus a dozen at the Lawrenceville headquarters as of March.

Other locations of Webcraft, which has 1,300 employees overall, are

in Chalfont and Bristol, Pennsylvania. It is owned by Vertis Direct

Marketing Service, which has more than 10,000 people.

The Mosso Group Inc., 436 Wall Street, Princeton

08540. Lisa A. Mosso, project director. 609-466-1234.

The Mosso Group, an event planning company specializing in medical

symposia, has moved from Research Park to 109 Cherry Brook Drive and

has a new phone number. Lisa Mosso’s father, Gus Mosso, founded the

company in 1990. "He was creative services director for Squibb

and planned meetings for them. I trained under my father."

Mosso majored in communications and theater at Trenton State College,

Class of 1984. After a brief shot at theater, she decided to join

her father in the business. In 1999 the firm was organizing oncology

meetings for Bristol Myers Squibb and moved from a home office to

Research Park.

Top Of Page
Leaving Town, Cranbury Business Park, Building 2,

Box 9707, Cranbury 08512-9707. Home page:

In April the catalog company closed its fulfillment center in Cranbury

and transferred all its shipping and billing services to a Tennessee

firm, National Fulfillment. As the largest fulfillment center in the

United States, National Fulfillment serves more than 150 companies

from this location: 6960 Eastgate Boulevard, Lebanon, Tennessee 37090.

Biddle Company Inc., 644 Whitehead Road, Trenton

08648. 609-392-4181; fax, 609-392-2859.

AMI Truck Lease bought the Biddle Company, a truck leasing firm, and

is moving this operation to Florence. The new owner is based in


Massachusetts (508-852-6493).

Roche Laboratories, 707 State Road, Gateway


Campus, Suite 106, Princeton 08540. 973-235-5000.

Roche Laboratories has closed its 2,100-foot business office at


Gateway. The office did sales and marketing for Roche products. Moving

into this space will be a sister company to Medarex, Genmab.

Anicom Inc. (ANIC), 1 Broadway Road, Suite 1,


08512. Rich Cohen, general manager east coast. 609-409-2832; fax,

609-409-4380. Home page:

This company went into Chapter 11 bankruptcy and is closing down,

both here at this 40-person warehouse, and at its headquarters in

Rosemont, Illinois (near Chicago). The multimedia technology firm

billed itself as distribution solution for voice, video, datapower

and security systems.

BAI Personnel Solutions Inc., 110 Stanhope Street,

Princeton Forrestal Village, Princeton 08540. Leigh Clayton,


609-919-9190; fax, 609-919-9655. Home page:

BAI Personnel Solutions has filed for Chapter 7 in the United States

Bankruptcy Court of Judge Stephen A. Stripp (Case number 01-52408).

The nine-year-old firm started as Bullock Associates, the in-house

placement agency for General Electric on Independence Way. In 1999

it had expanded, within Forrestal Village, to 2,300 square feet. It

did temporary and permanent placements.

Top Of Page
MarketFair Exec Takes Flight

Matthew Klutznick, manager of the MarketFair shopping

mall, competed in a crowded Route 1 retail market by creating a niche.

Under his watch, MarketFair, located in West Windsor, developed into

a collection of specialty stores catering to the nesting instincts

of affluent suburbanites. Klutznick, having overseen the mall’s


and signed on a number of new tenants, including Restoration Hardware,

Smith & Hawken, and Pottery Barn Design Studio, is moving on.

In his next gig Klutznick won’t have to worry much about what the

mall up the road is doing. He is trading a clientele of sometimes

fickle mall shoppers for a captive audience, one that, especially

on a foggy or snowy day, will be his — and his alone — for

many hours at a stretch. Klutznick is leaving MarketFair to become

director of retail operations for Midway and O’Hare International

Airports in Chicago.

Klutznick will be working for Reston, Virginia-based Unison-Maximus

Consulting, an aviation planning and consulting firm headquartered

in Chicago, where Klutznick grew up and where his father developed

12 malls and shopping complexes. Unison-Maximus specializes in


developing, and managing airport retail concessions. Its clients


Philadelphia International Airport, which has put up a billboard on

Route 95 showing an ecstatic couple sitting in rocking chairs backed

by palm fronds obviously enjoying the experience of being stranded

at an airport because of the shopping opportunities such a travel

glitch can offer. Newark International Airport, a facility not yet

known for its superior shopping, is another client.

Says Klutznick, "Unison recognizes the tremendous revenue


and community benefits offered by airport retail programs." As

he did at MarketFair, Klutznick will be hunting for and interpreting

demographic and regional data in his new job. "We’ll be looking

to bring new and innovative products that enhance the time the


spends at the airport," he says. "We want the airports to

provide a sense of place as well as uniqe shopping and dining


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