Expansions

New in Town

Down-Sizing

Crosstown Moves

Leaving Town

Deaths

Corrections or additions?

These articles were prepared for the February 14,

2001 edition of U.S. 1 Newspaper. All rights reserved.

3-Dimensional Pharmaceuticals

Sad news for one company can be good for another. In

this case, the good news was laboratory space, ready and waiting.

Advanced Medicine East (which started its life here as Transcell

Technologies)

moved everything, lock, stock, and barrel, out of Cedar Brook

Corporate

Center, leaving a well-equipped 32,000-foot laboratory behind. A

Pennsylvania

biotech, 3-Dimensional Pharmaceuticals, has seized this opportunity

to sublease state-of-the-art laboratory facility.

"It is very difficult to find existing laboratory space,"

says Scott Horvitz, vice president of finance at the company based

in Exton, Pennsylvania. It went public in August and trades on Nasdaq

as DDDP. "And this was predominately chemistry space, and we have

a strong emphasis in chemistry, with some other disciplines as

well."

This week 3-D Pharmaceuticals is moving into 8 Clarke Drive, at Route

130 and Dey Road. The staff will be 15 scientists and support

personnel,

but the space will hold 60 to 80 people, and these will be new hires.

Positions are open in combinatorial, medicinal, analytical, and

computational

chemistry, and also in protein biochemistry, molecular and cellular

biology, and crystallography. A facilities manager and systems

administrator

are also being hired.

The company has 40,000 feet in Exton, Pennsylvania, and Horvitz

reveals

that, on a long-term basis, it is beginning to consider a future space

somewhere between Exton and Cranbury in Mercer or Bucks County. 3DP

has grown by 30 percent, to 135 people, since its IPO in August, when

bids came in at the high end of the expected scale ($15) and the

maximum

number of shares, 5.75 million, were sold.

Roger F. Bone (senior vice president of R&D and a resident of

Somerville)

and Richard M. Soll (vice president of chemistry who lives in

Lawrenceville)

will split their time between the two facilities.

The name of the company dates back to when it was doing X-ray

crystallography

and structure-based drug design, which involves understanding the

three-dimensional structure of a target. It bills itself as "a

post-genomics drug discovery company dedicated to revolutionizing

a small-molecule discovery." One of its proprietary technologies

that accelerates drug discovery is DiscoverWorks, which

"capitalizes

on opportunities arising from human genome sequencing."

"We view this expansion as the continued progress of our

company,"

said David C. U’Prichard, CEO. "We are very proud of our

innovative

platforms for discovering new drugs in the post-genomics era."

"We believe we have a blend of superlative scientific, business

and administrative personnel at 3DP working together to advance

medical

science through the discovery of novel drug therapies," says Bone.

"The environment is stimulating and collegial."

3-Dimensional Pharmaceuticals Inc., 8 Clarke Drive,

Cedar Brook Corporate Center, Cranbury 08523. Richard Soll.

610-458-8959;

fax, 609-458-6056. Home page: www.3dp.com.

Advanced Medicine East, 650-808-6000 in California,

609-655-6900 in New Jersey. Home page: www.incara.com.

Top Of Page
Expansions

Polygenesis Corporation, 4270 Route 1 North, Suite

1, Monmouth Junction 08852. Henry Wieck PhD, president. 732-355-1001;

fax, 732-355-1002. Home page: www.polygenesis.com.

The five-year-old R&D development company expanded from 4270 Route

1 North to an address of 4262 in the same office park and added 1,500

feet for a total of 4,000. Barry Ginsberg of Bedminster has designed

the new space and it is being built out by Innovative General

Contracting,

to be ready in March. The firm has purchased a new computer network,

and the laboratory is replete with a full array of testing equipment

ranging from oscilloscopes to spectrometers.

Henry Wieck, the president, has degrees from Brooklyn College, Class

of 1972, and Rutgers, and was an early contributor to I-STAT, the

diagnostic blood analysis equipment company.

Polygenesis offers complete technology development capabilities,

including

mechanical design, software, electronics, and rapid prototyping (U.S.

1, August 30). Its MedManager monitors patient compliance with taking

medication.

Novaflux Technologies, 1 Wall Street, Princeton

08540. M.E. Labib, president. 609-683-0215; fax, 609-683-5003. Home

page: www.novaflux.com.

Finding new ways to clean high-tech medical equipment for re-use can

be a lucrative R&D business, as M.E. Labib has discovered. His firm,

Novaflux Technologies, formerly known as Princeton Trade and

Technologies,

has doubled its space at Research Park and opened a pilot facility

at 100 Jersey Avenue in New Brunswick.

The basic business is removing contaminants from tiny tubes. Princeton

laboratory focuses on medical and biotechnology applications, such

as high level disinfection of flexible endoscopes and reprocessing

hemodialyzers for dialysis clinics. Other technologies are related

to novel water treatment and topical drug applications —

antimicrobial

and antiviral applications.

Steve Weitzel, director of validation, says that Novaflux’ methods

are effective, low in cost, and minimize the effect on the

environment.

"For the medical devices, we are developing and applying

technology

for waste water and water purification membranes on a pilot basis.

In New Brunswick we are reprocessing reverse osmosis membranes,"

says Weitzel. The expanding company will sell the equipment, provide

the service in its own facilities, and license the technology to other

manufacturers.

Akros Pharma Inc., 214 Carnegie Center, Suite 302,

Princeton 08540. Tatsuya Yoneyama, president. 609-919-9570; fax,

609-919-9575.

A 13-year-old firm, based in Tokyo, Japan, has quadrupled in size

since it opened an office here last fall and has moved to an 8,100

square foot space in the Carnegie Center. Akros — the Greek word

for pinnacle — is overseeing clinical trials in the U.S. and

Europe,

establishing relationships with biotech companies and universities,

and arranging licensing agreements.

Top Of Page
New in Town

Shire US Inc., 212 Carnegie Center, Carnegie

Executive

Center, Suite 206, Princeton 08540. Lorraine A. Pronek, executive

assistant. 609-919-6330; fax, 609-520-1806.

The business development office of a pharmaceutical company, Shire

Pharmaceutical, moved to the Carnegie Center last year. It has its

headquarters in the U.K. and its U.S. headquarters in Kentucky.

Top Of Page
Down-Sizing

Gynetics Inc., 3371 Route 1, Suite 200,

Lawrenceville

08648. Norman Proulx, president and CEO. 609-919-1931; fax,

609-919-9409.

Home page: www.gynetics.com and www.preven.com

Gynetics, a firm that develops and markets drugs for women’s

healthcare,

moved from Raider Boulevard in Belle Mead to smaller quarters closer

to town, across from the Mercer Mall. It has five employees and 2,500

square feet. Its first product, the PREVEN Emergency Contraceptive

Kit, was the first FDA-approved product designed to prevent pregnancy

within 72 hours of unprotected intercourse.

Top Of Page
Crosstown Moves

Benecard Services, 168 Franklin Corner Road, Suite

201, Lawrenceville 08648. Douglas R. Forrester, president.

609-219-0400.

Home page: www.benecard.com.

Douglas Forrester moved his 10-year-old benefit

management

firm from 118 West State Street in Trenton to Franklin Corner Road.

He subcontracts to insurance companies to manage prescription and

vision programs for public and private sponsors of benefit plans.

As a Prescription Benefit Manager (PBM) he partners with a claim

processor,

National Prescription Administrators, to administer whatever benefit

design has been established by the employer. Most of his clients are

companies with at least 50 workers and are referred by a broker.

A philosophy and government major at Harvard, Class of 1975, Forrester

was the assistant state treasurer in the Kean and Florio

administrations,

and was also director of pensions and benefits. He has also taught

at the University of Pennsylvania. In the late 1980s he organized

the anniversary celebration for the War of the Worlds in West Windsor,

and he also served one year as mayor and two terms on the township

committee.

The relationship between PBMs and pharmaceuticals is a public policy

issue that deserves a lot more attention than it has received, says

Forrester. "People are finally waking up to how direct to consumer

advertising is influencing the way PBMs operate. Direct to consumer

advertising is counterproductive to public health and well being.

People should not be sold drugs like they are sold cars."

Top Of Page
Leaving Town

Clinical Trial Services, Drug Accountability and

Disposal

Division, 4204 Tech Avenue, Durham, NC 27704; 919-479-8850. Home

page: www.cts-usa.com.

Clinical Trial Services moved from 11 Princess Road to Durham, North

Carolina. It does packaging, distribution, accountability, and

disposal

of new and experimental drugs used in clinical research trials, and

was formerly known as J. Dana Associates Inc.

Advanced Magnetics Inc. (AVM), 104 Carnegie Center,

Suite 202, Princeton 08540-6232. Leonard M. Baum, senior vice

president.

609-520-8505; fax, 609-520-0620.

The regulatory affairs division of this pharmaceutical company was

closed and moved to the headquarters office: 61 Mooney Street,

Cambridge

02138-1038, 617-497-2070. It develops and manufactures MRI contrast

agents useful for cancer and liver disease.

The Medicines Company, 212 Carnegie Center, Suite

206, Princeton 08540. 617-225-9099; fax, 609-720-9810.

This pharmaceutical services company moved from the Carnegie Executive

Center to Cambridge, Massachusetts.

Top Of Page
Deaths

Nellie Hulit Meyers, 84, on February 4. She was a

bookkeeper

for Hulit’s shoes, founded by her father.

Anthony F. LaPlaca Sr., 83, on February 5. He was a home

builder and business consultant and the father of the owner of Joe’s

Mill Hill Saloon.

Cosmo A. Matticoli, 83, on January 7. He had been the

landscaper at Princeton Shopping Center.

Corrections or additions?


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